ZW800-1-1mg
ZW800-1 in FBSZW800-1 in PBSZW800-1 in DMSO

ZW800-1 (Carboxylic Acid)

Contact Us for Pricing

Contact Us for Pricing
Contact Us for Pricing
Contact Us for Pricing
Contact Us for Pricing

ZW800-1 is the world’s first “zwitterionic” NIR fluorophore, having geometrically-balanced and net-neutral poly-ionicity. It is engineered with peak emission ≈ 800 nm for use with Channel #2 of the FLARE® imaging system. Because of this unique chemical structure, ZW800-1 exhibits extremely low non-specific binding and uptake both in vitro and in vivo, and also exhibits ≈ 100% renal clearance and elimination from the body into urine after a single intravenous injection. During the elimination process, ZW800-1 highlights the ureters with an extremely high signal-to-background ratio for at least 60-90 minutes, making image-guided identification or avoidance of the ureters possible. After bolus intravenous injection, ZW800-1, in conjunction with the FLARE® imaging system, permits extremely high resolution NIR fluorescence angiography of arteries, capillaries, and veins. Because of its single carboxylic acid and no other reactive groups, ZW800-1 can also be used as a general-purpose labeling reagent, but is also available as a convenient reactive NHS ester or maleimide derivative for one-step conjugation. ZW800-1 is a member of the Ligand-Match™ family of labeling reagents and can help solubilize poorly soluble molecules.

FLARE® Imaging Applications
NIR angiography, ureter mapping, thoracic duct imaging, ligand labeling
General Information
Form ProvidedLyophilized powder
StorageSealed foil package can be stored at room temperature. Opened vials should be stored in a desiccator at RT or lower.
Packaging1 mg, 5 mg (1 mg x 5), 10 mg, 50 mg (10 mg x 5), plastic vial in mylar pouch with desiccant
Shelf LifeLyophlized powder is stable for up to 1 year. See lot-specific COA for details.
ShippingNormal shipping conditions
Selected References
Synthesis and in vivo fate of zwitterionic near-infrared fluorophores. Choi HS, Nasr K, Alyabyev S, Feith D, Lee JH, Kim SH, Ashitate Y, Hyun H, Patonay G, Strekowski L, Henary M, Frangioni JV. Angew Chem Int Ed Engl. 2011; 50: 6258-6263. PMID: 21656624
Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Choi HS, Gibbs SL, Lee JH, Kim SH, Ashitate Y, Liu F, Hyun H, Park G, Xie Y, Bae S, Henary M, Frangioni JV. Nat Biotechnol. 2013; 31: 148-153. PMID: 23292608
cGMP-Compatible preparative scale synthesis of near-infrared fluorophores. Hyun H, Bordo MW, Nasr K, Feith D, Lee JH, Kim SH, Ashitate Y, Moffitt LA, Rosenberg M, Henary M, Choi HS, Frangioni JV. Contrast Media Mol Imaging. 2012; 7: 516-524. PMID: 22991318
Near-infrared fluorescence imaging of thoracic duct anatomy and function in open surgery and video-assisted thoracic surgery. Ashitate Y1, Tanaka E, Stockdale A, Choi HS, Frangioni JV. J Thorac Cardiovasc Surg. 2011 Jul;142(1):31-8.e1-2. PMID: 21477818

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

Chemical Properties
Chemical Name2-[(E)-2-[(3E)-2-[4-(2-carboxyethyl)phenoxy]-3-{2-[(2E)-3,3-dimethyl-5-sulfonato-1-[3-(trimethylazaniumyl)propyl]-2,3-dihydro-1H-indol-2-ylidene]ethylidene}cyclohex-1-en-1-yl]ethenyl]-3,3-dimethyl-1-[3-(trimethylazaniumyl)propyl]-3H-indol-1-ium-5-sulfonate trifluoroacetate
CAS Number1239619-02-3 (Acid Form)
Chemical Structure (2D/3D)ZW800-1-CA PNG

Download ZW800-1CA ChemDraw File
Molecular Weight1057.25 as trifluoroacetic salt
Log D, pH 7.4-3.35 (JChem Calculation)
Typical purity (@210 nm/@peak absorbance)≥ 95%

Physicochemical Properties
Ligand-Match™ CompatibilityHydrophilic, 800 nm
SOLVENTSOLUBILITY (Super-Saturation Method)
PBS, pH 7.432.7 mg/mL (31 mM)
100% serum, pH 7.426.7 mg/mL (25.2 mM)
DMSO2.9 mg/mL (2.8 mM)

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

FLARE® Channel Compability
Channel #2 (≈ 800 nm NIR fluorescence)
OPTICAL PROPERTIESPBS, pH 7.4100% serum, pH 7.4DMSO
Excitation Max (nm)768770792
Emission Max (nm)786788808
Stokes Shift (nm)181816
Extinction Coefficient (@ Ex max)235,000254,000251,000
Quantum Yield (%)13.515.126.5

ZW800-1 in DMSO

ZW800-1 in PBS

ZW800-1 in FBS

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.