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Lab-FLARE® Model R1 Open Space Imaging System

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The Lab-FLARE® Model R1 is a state-of-the-art open space imaging system that uses a patented technology to enable truly simultaneous acquisition of color video and two different wavelengths of NIR fluorescence. It is a true workhorse for laboratory research that includes A/D, D/A, TTL inputs and outputs, and relays, along with a scripting language that enables automation of complex repetitive experiments. The low-profile imaging head is connected to the cart via a long-reach, electromagnetically-braked arm permitting 6-DOF motion and one-button brake release. Accessories for sterile operation and reduction of reflection artifacts are also available.

Please see the Research Acceleration Program for cost saving options.

FLARE® Imaging Applications
In vitro NIR fluorescence assays, in vivo NIR fluorescence assays, development of novel NIR fluorescent contrast agents, cryofluorescence tomography.
General Information (see Specifications Tab for Details)
FOVVariable from 0.9 cm to 25.3 cm
Working DistanceVariable from 12" to 18"
ResolutionVariable from 50 µm to 500 µm
Illumination Wavelength Bands3 (Color Video, NIR Channel #1, NIR Channel #2)
Simultaneous Imaging Channels3 channels (Color Video, NIR Channel #1, NIR Channel #2)
Sterile UseYes via proprietary drape/shield combinations. See Accessories tab.
PortabilityYes. 4" medical grade casters with individual brakes
ShippingRe-usable, water-resistant, fire-resistant, shock-resistant shipping crate
DisclaimerFor laboratory research use only. Not for use in diagnostic procedures. Not for human or veterinary use.
Selected References
Image-guided cancer surgery using near-infrared fluorescence.
Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJ, Frangioni JV.
Nat Rev Clin Oncol. 2013 Sep;10(9):507-18. doi: 10.1038/nrclinonc.2013.123. Epub 2013 Jul 23. Review. PMID: 23881033
Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation.
Gioux S, Choi HS, Frangioni JV.
Mol Imaging. 2010 Oct;9(5):237-55. Review. PMID: 20868625
Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer.
Mieog JS, Troyan SL, Hutteman M, Donohoe KJ, van der Vorst JR, Stockdale A, Liefers GJ, Choi HS, Gibbs-Strauss SL, Putter H, Gioux S, Kuppen PJ, Ashitate Y, Löwik CW, Smit VT, Oketokoun R, Ngo LH, van de Velde CJ, Frangioni JV, Vahrmeijer AL.
Ann Surg Oncol. 2011 Sep;18(9):2483-91. doi: 10.1245/s10434-011-1566-x. Epub 2011 Mar 1. PMID: 21360250
The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping.
Troyan SL, Kianzad V, Gibbs-Strauss SL, Gioux S, Matsui A, Oketokoun R, Ngo L, Khamene A, Azar F, Frangioni JV.
Ann Surg Oncol. 2009 Oct;16(10):2943-52. doi: 10.1245/s10434-009-0594-2. Epub 2009 Jul 7. PMID: 19582506

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

CategorySpecificationDescription
PhysicalSize (retracted)24” (W) x 24” (D) x 68” (H)
Weight450 lbs.
Casters4” anti-static medical grade casters
Over-balance protection≤ 10˚ Tilt
ElectricalAC voltageUniversal (100-240 V; 50/60 Hz)
AC receptacleMedical grade C14 male
AC power cordMedical grade C13 female, 4 m, black; USA, Europe, UK, Switzerland, Australia, or Japan available
Current10 A @ 110 V (double-fused)
Power900 W
Leakage current< 300 µA
Earth Ground≤ 0.1 W
ComputingOS & softwareProprietary
InterfacesWi-Fi, Ethernet, USB, and Bluetooth
Cart monitors2 @ 4K UHD (3840 x 2160)
External monitor receptacles2 @ DisplayPort
Speakers2W speakers built into monitors with additional 1/8" female stereo out and Bluetooth out
User interfaceKeyboard, trackpad, 6-pedal Bluetooth® wireless footswitch, webcam
Experimental interfaceScript control of illumination, acquisition, and scientific interface
Imaging HeadStabilityNormally-on electromagnetic braking
Brake releaseOne-button
Motion6 degrees of freedom
Auto-calibrationAutomatically at start-up with imaging head in parked position
OpticsReach42-62” from floor
12-54” from center mast
Working distanceVariable 12" - 18"
LensCustom 15X macrozoom
Motorized zoom and focus
Aberration corrected 400-900 nm
Distortion ≤ 2% at max WD and no zoom
Vignetting ≤ 5% at max WD and no zoom
Diagonal FOV range @ 12" WD0.9 - 14.5 cm
Diagonal FOV range @ 15" WD1.3 - 20.0 cm
Diagonal FOV range @ 18" WD1.7 - 25.3 cm
System resolution50 µm - 500 µm depending on WD and zoom
Simultaneous imaging windows3 (color video, NIR Channel #1, NIR Channel #2)
Color video channel illumination400-660 nm
On/off and intensity control
≥ 10,000 Lx at all working distances
CRI ≥ 85
Color temperature ≈ 4,500 K
Color video channel imaging400-650 nm
NIR Channel #1 illuminationLaser Class 3R
665 ± 3 nm
2-4 mW/cm2
On/off and intensity control
NIR Channel #1 imaging685-735 nm
NIR Channel #2 illuminationLaser Class 3R
760 ± 3 nm
5-10 mW/cm2
On/off and intensity control
NIR Channel #2 imaging≥ 781 nm
Image resolution1024 x 1024 pixels; binnable to 2 x 2, 4 x 4, or 8 x 8
Bit depth10-bits each for red, green, blue, NIR Channel #1 and NIR Channel #2
Exposure time66 µsec to 3 sec; each imaging channel capable of independent exposure time
Readout rates20 Hz at full resolution
32 Hz at 2 x 2 binning (grayscale color only)
Higher rates possible when using smaller ROIs
Scientific InterfaceA/D converters2
Input: -2.5 to 2.5 V; isolated to ?????
DSP: low-pass, high-pass, band-pass, gain
D/A converters2
Output: -2.5 to 2.5V; 20 mA max
TTL In2
TTL Out2
20 mA max
Relays2
Type SPDT
Each NC/NO; 10 A @ 250 V AC or 10 A @ 24 V DC max
Sterile OperationDrape & shield (one-time use)Gamma-irradiated
Hermetically sealed drape/shield combination
Anti-reflective
≥ 94% transmission from 400-900 nm
Air flowFans and air motion under cart only

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.

Disclaimer: For laboratory research use only. Not for use in diagnostic or therapeutic applications. Not for human or veterinary use.